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Tuberculosis

Humoral responses to Mtb and BCG
Accumulating evidence suggests a role for humoral immunity in preventing and alleviating TB.  Nevertheless, the specificity, heterogeneity and function of B cells in the lung mucosa during TB infection are poorly understood.  In this project we aim to:


1. identify surface exposed mycobacterial antigens targeted by antibodies isolated from the lungs of mycobacteria infected mice
2. 
investigate the dynamics and transcriptional regulation of B cells responding to mycobacteria in the lung and peripheral lymphoid organs
3. 
assess the functional potential of mycobacteria specific antibodies isolated from the lung and serum
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