Humoral responses to Mtb and BCG
Accumulating evidence suggests a role for humoral immunity in preventing and alleviating TB. Nevertheless, the specificity, heterogeneity and function of B cells in the lung mucosa during TB infection are poorly understood. In this project we aim to:
1. identify surface exposed mycobacterial antigens targeted by antibodies isolated from the lungs of mycobacteria infected mice
2. investigate the dynamics and transcriptional regulation of B cells responding to mycobacteria in the lung and peripheral lymphoid organs
3. assess the functional potential of mycobacteria specific antibodies isolated from the lung and serum
Accumulating evidence suggests a role for humoral immunity in preventing and alleviating TB. Nevertheless, the specificity, heterogeneity and function of B cells in the lung mucosa during TB infection are poorly understood. In this project we aim to:
1. identify surface exposed mycobacterial antigens targeted by antibodies isolated from the lungs of mycobacteria infected mice
2. investigate the dynamics and transcriptional regulation of B cells responding to mycobacteria in the lung and peripheral lymphoid organs
3. assess the functional potential of mycobacteria specific antibodies isolated from the lung and serum