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TFH cells - the condemned live longerWe've been studying the survival and fitness of TFH memory cells revealing their persistence for more than 400 days after LCMV infection. However, these cells have previously been overlooked due to their susceptibility to NAD-induced cell death. Long-lived TFH cells are plastic upon re-activation and Inhibiting these cells at late time point after infection revealed a previously unknown functional role in contributing to the maintenance of humoral immunity.
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Hold your breath - CD4 TRM heterogeneity in the lungWe've identified two distinct CD4 TRM populations in the lung upon Influenza infection which we call TRM1 and TRH. TRM1 resemble Th1 cells in the spleen, whereas TRH are reminiscent of TFH. TRH are generated in the lung from a common TRM precursor, are dependent on Bcl6 and B cells for their differentiation, and contribute to local humoral immunity.
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TuberculosisThe largest barrier to development of an effective TB vaccine is our failure to understand the fundamental characteristics of a protective immune response. Dissecting the biology underlying protective versus pathogenic immunity to TB requires an integrated understanding of the cellular ecosystem.
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CD4+ Memory T cells at Home in the TissuesDuring the last 10 years, a population of clonally expanded T cells that take up permanent residence in non-lymphoid tissues has been identified. The localization of these tissue resident memory (TRM) cells allows them to rapidly respond at the site of antigen exposure, making them an attractive therapeutic target for various immune interventions. In our review, we highlight the similarities of CD8 and CD4 TRM.
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